Assay Name |
Platform |
Species |
Matrix |
Metabolic Stability |
LC-MS/MS |
Mouse, Rat, Dog, Monkey, Human |
Liver microsomes, hepatocytes, intestine microsomes, skin homogenates |
CYP inhibition |
LC-MS/MS |
human |
liver microsomes |
Plasma protein binding |
LC-MS/MS |
mouse, rat, dog , monkey, human |
Plasma |
Red blood cell partitioning |
LC-MS/MS |
mouse, rat, dog, monkey, human |
Fresh blood |
Metabolite profiling |
LC-MS/MS |
mouse, rat, dog, monkey, human |
Microsomes, hepatocytes, plasma, excreta, urine, feces |
Permeability |
Cell-based assay |
human |
MDCK, CaCo-2 |
CYP induction |
Cell-based assay |
human |
hepatocytes |