Assay Name Platform Species Matrix
Metabolic Stability LC-MS/MS Mouse, Rat, Dog, Monkey, Human Liver microsomes, hepatocytes, intestine microsomes, skin homogenates
CYP inhibition LC-MS/MS human liver microsomes
Plasma protein binding LC-MS/MS mouse, rat, dog , monkey, human Plasma
Red blood cell partitioning LC-MS/MS mouse, rat, dog, monkey, human Fresh blood
Metabolite profiling LC-MS/MS mouse, rat, dog, monkey, human Microsomes, hepatocytes, plasma, excreta, urine, feces
Permeability Cell-based assay human MDCK, CaCo-2
CYP induction Cell-based assay human hepatocytes