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Metabolism Studies

lab
  • Metabolic stability (Intrinsic clearance)
  • Direct and mechanism-based inhibition
  • CYP induction
  • Reaction phenotyping
  • Drug-drug interactions between small molecules and biologics
  • MDCK/MDCK-MDR1 cell permeability
  • Protein binding in plasma/whole blood
  • Metabolite profiling, isolation, purification and identification
  • Predictive routes of metabolism and potential toxicity
  • In vitro species comparisons for appropriate pre-clinical animal model selection