Cell based assays utilize defined cells to gather information on a biopharmaceutical candidate. Commonly, cell based assays are employed during drug discovery stages to identify parameters such as potential drug cytotoxicity, mechanism of action, and biological activity. These types of analysis provide a cost-effective and reliable indication of drug activity in a living system and can be used to measure the chosen aspects over time. Cell based assays during pre-clinical studies are used to establish a stronger rationale to move forward a biopharmaceutical into animal and even human subjects.

Alliance Pharma Biopharmaceutical Department conducts cell based assays to monitor a variety of biopharmaceutical outcomes. Cell proliferation, viability, apoptosis, and cytotoxicity assays as well as permeability assays have been validated. We also have expertise in cytokine induction and/or inhibition assays. Cell based assays have also been validated to measure the presence of neutralizing anti-drug antibodies (ADA) in response to biopharmaceuticals.

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