NEWS: Our Blog

RESOURCES: 2022 National Biotechnology Conference Posters

May 13, 2022 10:30:00 AM / by Alliance Pharma posted in Conferences, Posters

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Alliance Pharma is proud to have presented the posters listed below at the AAPS National Biotechnology Conference in 2022.

Click poster images below to download a PDF file.

 


A Lesson Learned in Developing the Ligand Binding Assay for Quantification of Complement C3a

Alliance Pharma NBC 2022

 



Is Linear Regression Curve Fitting the Best Model for Stem-Loop RT-qPCR Data Analysis?

Alliance Pharma 2022 NBC Poster

 

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AlliancePharma Announces Launch of Professional Services Quoting Application, PSQuote from CLD Partners

Apr 29, 2022 3:57:19 PM / by Alliance Pharma

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MALVERN, Pa.,
 April 29, 2022 /PRNewswire/ -- This week, AlliancePharma (Malvern, PA) announced their go-live of PSQuote together with CLD Partners (Front Royal, VA). PSQuote is a newly developed professional services quoting application built on the Salesforce platform (PSQuote is a wholly-owned division of CLD Partners). AlliancePharma will use the tool to enhance and elevate their sales cycle, delivering a better customer sales experience--from quote to service delivery. CLD Partners has engaged with AlliancePharma since June 2021, for FinancialForce implementation services, and this new deployment is the next step in a growing business relationship.

AlliancePharma is a contract research organization (CRO) specializing in drug metabolism and pharmacokinetics (DMPK) and bioanalytical services for both small and large molecules. They serve clients throughout the development lifecycle, from pre-clinical/clinical trials to market entry. AlliancePharma works closely with their clients, allowing full access to data, creating strong partnerships and walks, side-by-side, with them through their project development.

Over the years, CLD Partners has built many custom professional services estimation tools based on the Salesforce platform, including for many large enterprises. They developed the expertise and experience from responding to a consistent request–how can a client more fully automate their quoting process and bridge the gap between their CRM and PSA (Professional Services Automation) tools.

With PSQuote deployed, AlliancePharma will now leverage the power of the Salesforce platform to centralize and standardize their quoting process, which will fuel their growth as they expand into other regions. Ryan Klein, Senior Director of Business Development and the executive sponsor for the implementation, said, "PSQuote is the right tool at the right time. We are aggressively scaling our organization to achieve growth goals over the next several years, and getting the right tools in place is key. We know PSQuote is going to grow with us, and we're grateful for CLD Partners' excellent implementation work."

CLD Partners CEO, Steve Clune, who originally designed PSQuote, sees this as a further step in CLD offering specific expertise to the CRO space. "Contract Research Organizations have unique challenges in transforming their workflows to a more automated and digital system. Through implementing FinancialForce with multiple CRO clients, including AlliancePharma, we have gained expertise in this space. And now, in deploying PSQuote, we're enhancing our solution offering to these organizations. I am excited to grow our practice for CROs even more."

PSQuote is a native Salesforce application available on the AppExchange

 

SOURCE CLD Partners

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Alliance Pharma Appoints Patrick Bennett as Chief Executive Officer

Apr 12, 2022 4:51:57 PM / by Alliance Pharma posted in Leadership, CEO, Philadelphia, Patrick Bennett

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Alliance Announcement of New CEO
Malvern, PA, March 25, 2022
- Alliance Pharma, a leader in small and large molecule bioanalytical services in the pharmaceutical and biopharmaceutical industry, announces that Patrick Bennett has been named Chief Executive Officer. Bennett has more than 30 years of experience in the industry, including 25 years in leadership roles at various bioanalytical contract research organizations, most recently as Vice President, Strategy and Development at PPD Laboratories. Prior to PPD, Bennett served as the Director of Global Strategic Marketing at ThermoFisher Scientific, and at various executive level positions with Tandem Labs. Frank Li, Founder of Alliance Pharma, is transitioning leadership to Bennett but will remain a key member of the Alliance team and serve as its President and on its Board of Directors. Throughout his career, Patrick has developed broad bioanalytical expertise and established a strong reputation as a leader and innovator in laboratory operations. In his most recent roles, he established biomarker, cell and gene therapy operations, and a state-of-the-art bioanalytical lab in China.

“Alliance will execute an aggressive global growth strategy, and there is no one more timely, skilled, or better suited to lead Alliance than Pat. His operational expertise, global experience, long-term relationship-driven nature, and exceptional communication skills are a perfect fit for Alliance” explained Dave Patteson, Chairman of the Board at Alliance and a Partner at Ampersand, Alliance’s principal owner.

“Frank Li has founded, built, grown and led an exceptional bioanalytical service offering and team of premier scientists, serving the pharma/biopharma industry. Our vision is to build upon this knowledge and experience, allowing Alliance to fulfill its mission as a complete global bioanalytical service provider for all drug modalities”, Patrick Bennett, New CEO of Alliance Pharma, commented.

 

About Alliance Pharma

Founded in 2008, Alliance is a contract research organization (CRO) in Malvern, PA just outside of Philadelphia that specializes in advanced bioanalytical research services for both small and large molecule drugs, as well as drug metabolism studies to support pharmaceutical and biotechnology companies’ drug discovery and development programs. Alliance’s mission is to build a trusted partnership with our clients to support their successful drug development programs. Our business philosophy is based on a foundation of trust, professional ethics, scientific excellence and regulatory compliance.

 

About Ampersand Capital Partners

Founded in 1988, Ampersand is a middle market private equity firm with more than $2 billion of assets under management dedicated to growth-oriented investments in the healthcare sector. With offices in Boston and Amsterdam, Ampersand leverages its unique blend of private equity and operating experience to build value and drive superior long-term performance alongside its portfolio company management teams. Ampersand has helped build numerous market-leading companies across each of the firm's core healthcare sectors. Additional information about Ampersand is available at ampersandcapital.com.

 

 

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RESOURCES: 2021 Posters

Mar 15, 2022 3:22:02 PM / by Ryan Klein posted in Conferences, Posters

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Alliance Pharma is proud to have presented the posters listed below at many of the industry leading conferences throughout 2021.

Click poster images below to download a PDF file.

 


A Fast and Robust Quantitative Assay for Dekaparin in Dog Plasma by Heparan Lyase Digestion Coupled to UPLC-MS/MS

2021 Posters

 


A Sensitive and Fast Assay to Quantify Cannabidiol and Tetrahydrocannabinol in Human Urine Using Microelution SPE Coupled With UPLC-MS/MS Analysis

2021 Posters

 


A Rapid, Robust, Sensitive, and High-Throughput UPLC-MS/MS Assay to Quantitate Murine Double Minute 2 (MDM2)-p53 Inhibitor Alrizomadlin in Human Plasma

2021 Posters

 


A Simple, High-throughput, and Sensitive UPLC-MS/MS Assay to Quantify Abiraterone Acetate in Human Plasma

2021 Posters

 

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Ampersand Invests in Alliance Pharma, Leading Bioanalytical CRO

Nov 19, 2021 10:23:36 AM / by Ryan Klein posted in Leadership, Feng Li, CEO, success, Growth

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WELLESLEY, MA, November 18, 2021 /PRNewswire/ -- Ampersand Capital Partners, a private equity firm specializing in growth equity investments in the healthcare sector, has announced an investment in Alliance Pharma (“Alliance”), a global leader in large and small molecule bioanalytical services. Headquartered in Malvern, PA., Alliance provides a full suite of discovery bioanalytical, DMPK, regulated bioanalysis, biomarker, LC-MS/MS, immunoassay, cell and gene therapy, and protein characterization assays. These capabilities support preclinical-through-Phase 4 studies run by a global customer base comprised of leading pharma and biotech companies.

Dave Patteson, Partner at Ampersand, stated "We are very excited to complete this investment in Alliance and partner with Founder and President Frank Li, who will remain a significant shareholder in the Company. Ampersand’s goal is to help Alliance execute an aggressive growth strategy that will expand the Company’s global reach, scientific capabilities, and operational capacity.”

Frank Li, President of Alliance, stated "We are delighted to have Ampersand invest in Alliance. Ampersand’s deep industry expertise, broad network, and capital resources will fortify Alliance Pharma’s position as a market-leading global specialty CRO."


About Alliance Pharma

Founded in 2008, Alliance is a contract research organization (CRO) that specializes in advanced bioanalytical research services for both small and large molecule drugs, as well as drug metabolism studies to support pharmaceutical and biotechnology companies’ drug discovery and development programs. Alliance Pharma provides: quantitative LC-MS/MS analysis of small molecule drugs, metabolites, biomarkers, protein, peptides and oligonucleotides, as well as protein characterization services; immunoassay of proteins and antibody drug conjugates;immunogenicity assays (anti-drug antibody screening, confirmation, titer assessment, and Nab determination): cell-based bioassays; in vitro and in vivo drug metabolism and pharmacokinetic studies.

Alliance’s mission is to build a trusted partnership with our partners & clients to support their successful drug development programs. Alliance’s business philosophy is based on a foundation of trust, professional ethics, scientific excellence and regulatory compliance.


About Ampersand Capital Partners

Founded in 1988, Ampersand is a middle market private equity firm with more than $2 billion of assets under management dedicated to growth-oriented investments in the healthcare sector. With offices in Boston and Amsterdam, Ampersand leverages its unique blend of private equity and operating experience to build value and drive superior long-term performance alongside its portfolio company management teams. Ampersand has helped build numerous market-leading companies across each of the firm's core healthcare sectors. Additional information about Ampersand is available at ampersandcapital.com.

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> Our Expansions and Added Resources in 2020

Nov 16, 2020 9:00:00 AM / by Ryan Klein posted in Pharmaceuticals, Conferences, DMPK

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How has 2020 treated your company? It has been an odd year to say the least, and we are extremely grateful for the opportunities we have had in our field to work alongside and support companies, such as yours, providing medications to help people live the fullest life possible.

While we have been working with our clients on their exciting projects, we have also been working internally on growing! During the past 12 months we have expanded our footprint and capabilities within our current facility as we continue to build trusted partnerships with you – our clients! We have done this by adding the following:

Space

  • 3,000 square feet of additional office space
  • Three additional laboratories that cover approximately 1,600 square feet
  • OHC 3 – 5 lab facility
  • A BSL3 lab facility will be completed in the fourth quarter of 2020

Equipment

  • Two Agilent 6495 QqQ LC-MS/MS instruments
  • Two Agilent 8900 Triple Quad ICP-MS instruments
  • Validated Agilent Mass Hunter software
  • Two Sciex 6500+ LC-MS/MS instruments
  • New Gyrolab xPlore
  • Upgraded Watson LIMS to version 7.6.1
  • One Agilent Bio-Inert UHPLC

Staff

We have also seen a 15% growth in our staff! We continually look for scientists, lab assistants and techs, IT specialists, software developers, business development/marketing, quality assurance, fellows, and report reviewers for example. We invite you to review our openings on our website and consider joining our role serving the pharmaceutical, biotech, and agrochemical industries, as well as academia.

We look forward to working with you in the months wrapping up 2020 as well as in 2021 with our increased space, resources and staff! Please reach out to us at 610-296-3152 or info@alliancepharmaco.com to discuss how our space, equipment and staff can best meet your drug development and drug metabolism project needs.



Any further questions or need an answer?  Please contact Ryan Klein at rklein@alliancepharmaco.com or 919-801-3146.

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> Making the Most of Your Virtual Conference Experience

Nov 10, 2020 2:00:00 PM / by Ryan Klein posted in Pharmaceuticals, Conferences, DMPK

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Remember when we used to meet in person for our conference experiences? We would gather at conference centers and hotel complexes to attend great seminars, to have insightful conversation, to reconnect with old friends and to make new friends. Everything has changed this year as we all continue to adapt to the COVID-19 pandemic. We understand that many of us are sad about what we may miss, but we are thankful for the technology available that allows us to still attend conferences virtually. We know great interactions, education and conversations can still occur even if it has to happen online!

Our latest blog offers tips on how you can make the most of your virtual conference experience. We hope these tips help you as you adapt to our “new normal”. We look forward to seeing and meeting with you during virtual events in the months ahead. Thank you for the trust you put into us with your drug development and drug metabolism projects!

Tips for attending a virtual conference

We are all used to packing our bags, traveling and preparing for our interactions when it comes to attending conferences. COVID-19, however; has changed all of that this year. As many conferences are turning into virtual events, we thought we’d highlight some ways you can get the most out of your virtual conference experience.

  • Prepare mentally for attending the conference. You don't want to just "show up" online. Be prepared with any prep work you would have done prior to an in-person conference. This includes being aware of any potential distractions surrounding you, including your email and phone notifications. It’s tempting to try and multi-task in this circumstance, but do what you can to stay focused on the meeting, just like you would if you attended in person.

  • Be bold. Just as you wouldn't attend an in-person conference and stay in your room the entire time, except for a session or two, you must also be bold in these virtual settings. That means being willing to ask the questions, make the introductions and network. Many virtual conference platforms are offering video chats. Don’t be afraid to ask someone for a face-to-face call.

  • Be active on social media. Social media is a great tool for staying connected and asking questions before, during and after a virtual conference. If you aren't comfortable asking in a live event, use that hashtag to ask your questions on social media channels. Not sure you want your question in public spaces? Follow the social media channels of the conference host, speakers, panelists, sponsors, vendors and attendees, and use those direct message features or find the contact info for that direct email or phone call.

  • Take time to stroll. At a conference, you may pick up a cup of coffee and stroll through the booth areas. Do the same with virtual booth access. Vendors are supporting the virtual meeting through funding and their presence at the meeting. Provide some support for them by visiting the virtual booth and learning about their services in between presentations and during the times dedicated to the virtual exhibit hall.

  • Be patient! Just as you are learning to now navigate a virtual conference, so are all the other attendees, vendors and hosts. There will be times when technology doesn't work right, people forget to mute themselves or even random hiccups occur. Some of it may even feel awkward. Through it all, remember we are all working to adapt in the midst of all the changes COVID-19 has brought this year.

  • Don’t leave early. That last session or final connection may just be the one that makes a difference for you and your company. Make sure to take full advantage of the entire schedule and resist the temptation to head to the couch early.

You can find our conference schedule on our website and our social media channels. Please remember we may not have a table set up around the corner of the conference hall, but we are here to answer any of your questions and welcome your conversation. Visit us at our virtual booth and chat with our team through the virtual conference links at our scheduled events. You are also always welcome to contact us at 610-296-3152 or info@alliancepharmaco.com.

We look forward to seeing you at that next virtual conference!


If you’re going to any upcoming conferences and would like to meet with us, please contact Ryan Klein at rklein@alliancepharmaco.com or 919-801-3146.

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> POSTERS: 12th International ISSX Meeting

Nov 15, 2019 10:30:00 AM / by Ryan Klein posted in Pharmaceuticals, Conferences, DMPK

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Seven hundred scientists, students, and exhibitors convened at the Oregon Convention Center in Portland, Oregon, USA this past July 28–31 for ISSX2019.

Alliance Pharma is proud to have presented the three posters below.
Click poster images below to download a PDF file.

invitroDDIjpg

 

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If you’re going to any upcoming conferences and would like to meet with us, please contact Ryan Klein at rklein@alliancepharmaco.com or 919-801-3146.

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> University of Wisconsin Land O’Lakes DMPK Conference

Sep 6, 2019 10:00:00 AM / by Alliance Pharma posted in Pharmaceuticals, Conferences, DMPK

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University of Wisconsin Land O’Lakes DMPK ConferenceThe Land O’Lakes conference series is one of the longest running and most revered teaching conferences in the pharmaceutical industry. Over the last two decades, the Land O’Lakes conferences have been developed by the division of pharmacy professional development within the school of pharmacy at the University of Wisconsin-Madison and have an impeccable reputation within the pharmaceutical industry for shedding light on cutting edge topics, bringing in knowledgeable experts and having an intimate setting which lends itself to some fantastic networking opportunities. 

We at Alliance Pharma are pleased to announce that we will be attending the 22nd annual Land O’Lakes conference on Drug Metabolism and Applied Pharmacokinetics on September 9th thru September 12th in Madison, Wisconsin. We are excited and eager to hear from industry leaders on the new advances in drug delivery, action and metabolism. This years’ meeting is titled ‘Found in Translation: Adaptive DMPK Strategies’, and will include topics focused on target mediated drug disposition (TMDD), endogenous biomarkers and more.


Target mediated drug disposition requires that we think outside the box in terms of drug distribution and elimination from the body. TMDD often exhibits nonlinear pharmacokinetics and pharmacodynamics due to the drugs unusually high affinity to a binding site.


Endogenous biomarker research, particularly in the drug transporter area, continues to rapidly evolve. Our biomarker team at Alliance is a highly experienced team with significant expertise in biomarker method development and analysis, yet we are always eager to learn more!


If you’re going to the conference and would like to meet with us, please contact Ryan Klein at rklein@alliancepharmaco.com or 919-801-3146.

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> Comparing Methods for Assessing In-Vitro Protein Binding

May 6, 2019 4:00:00 PM / by Taylor MacArthur and Jessica Lipponen posted in Pharmaceuticals

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           The extent of binding to proteins is an important parameter to assess when screening drug candidates during in-vitro ADME studies. Assessing the free fraction of drug available in the biological system is critical to understanding its distribution potential, as it is generally believed that the free fraction drives therapeutic outcomes since it is the free drug (that which is not bound to proteins) that can move to and interact with the sites of action, and high binding to proteins can affect the metabolism and elimination of the drug.

          There are three methods most commonly used to assess protein binding, and it is important to assess their advantages and disadvantages when selecting methods to use for screening studies.

Rapid Equilibrium Dialysis (RED) makes use of a device with two chambers separated by a semipermeable membrane. Spiked matrix is added and over an incubation period, the free drug comes to equilibrium across the membrane while proteins and protein-bound drug cannot move across the membrane; free fraction is calculated by comparing the concentration of drug from the protein and protein-bound drug side to the protein-free, free drug side.

#1#2

Advantages: Most common method (easy cross-comparisons), simple apparatus/setup and high throughput

Disadvantages: Requires long-term stability in the matrix (typical incubation period is 4 hours), nonspecific binding to the device/membrane, volume shifts and protein leakage over the incubation period.

Ultracentrifugation (UC) uses high-speed centrifugation to precipitate proteins and protein-bound drug from a spiked matrix; free fraction is calculated by comparing the concentration of drug in the protein-free supernatant and the intact spiked matrix.#4Advantages: Avoids membrane-related issues (nonspecific binding, leakage across membrane, etc.)

Disadvantages: Usually low-throughput, harder to control pH, temperature (conditions that can significantly affect protein binding), requires longer-term stability in matrix (typical centrifugation time is two hours), the supernatant may not be completely protein-free, leading to an artificially high free fraction observed.

Ultrafiltration (UF) uses a two-chambered device separated by a semipermeable filter. Spiked matrix is loaded into the device and centrifuged at moderate speed, during which time free drug passes through the filter while proteins and protein-bound drug cannot; free fraction is calculated by comparing the concentration of drug in the protein-free filtrate and the intact spiked matrix.

#5Advantages: Suitable for unstable compounds (typical centrifugation time is 30 minutes), quick and technically simple, high throughput/useful to screen many compounds to rank free fraction

Disadvantages: Nonspecific binding to the filter membrane or collection chamber (under-estimation of free fraction), molecular sieving may occur (liquid moves through filter more quickly than the drug, under-estimating free fraction)

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