Bioanalytical LC-MS/MS Method List 

With 20+ years of working to GLP and GCP, we have developed an extensive number of LC-MS/MS bioanalytical methods in a wide range of species and matrices. These have been established/validated in line with the latest EMA/FDA guidance and applied in the quantitation of therapeutic drugs, metabolites and biomarkers.

Assay Experience

The following list details our bioanalytical LC-MS/MS method experience.

Some of these methods may require re-establishment or validation prior to use.

We have also developed and validated many more proprietary methods across a broad range of species and matrices.

If an analyte of interest is not listed, please get in touch and we can discuss setting up a method to support your project requirements.


 

 Analyte name  Calibration curve range
 (LLOQ-ULOOQ)
 Species  Matrix  Anticoagulant  Sample 
 volume (μL)
 Storage  temperature
Aldosterone 5 - 500 pg/mL Human Plasma K2 EDTA 300 -80
Aldosterone 0.1 - 50 ng/mL Human Urine N/A 100 -80
Androstenedione 0.1 - 100 ng/mL Human Plasma K2 EDTA 200 -20
Angiotensin I
(Plasma Renin Activity)
0.2 - 200 ng/mL Human Plasma K2 EDTA 100 TBC
Aripiprazole
Olanzapine
Quetiapine
Risperidone Paliperidone
5 - 500 ng/mL
0.2 - 100 ng/mL
5 -500 ng/mL
0.1 - 100 ng/mL
0.2 - 100 ng/mL
Human Plasma K2 EDTA 100 -20
Atorvastatin
2-Hydroxy Atorvastatin
4-Hydroxy Atorvastatin
20 - 20000 pg/mL
20 - 20000 pg/mL
10 - 1000 pg/mL
Human Plasma K2 EDTA 100 -20
Budesonide 10 - 10000 pg/mL Human Plasma NaF / KOx 250 -20
Buprenorphine Norbuprenorphine 2 -1000 pg/mL
5 - 1000 pg/mL
Human Plasma K2 EDTA 400 -20
C4
(7 -hydroxy-4-cholensten-3-one)
2 -500 ng/mL Human Plasma Lithium Heparin 100 -20
Ciprofloxacin 100 - 4500 ng/mL Human Plasma Lithium Heparin 50 -20
Clopidogrel
Clopidogrel acid
10 - 5000 pg/mL
30 - 4000 ng/mL
Human Plasma Lithium Heparin 100 -80
Clozapine 5 -1000 ng/mL Human Plasma K2 EDTA 50 -20
Cortisol 1 - 500 ng/mL Human Plasma K2 EDTA 200 -20
Cortisol 0.2 - 20 ng/mL Human Saliva N/A 200 -20
Cortisol 0.6 - 300 ng/mL Human Urine N/A 200 -20
Cortisol
11-Deoxycortisol
Corticosterone
11-Deoxycorticosterone
1 - 250 ng/mL
20 - 2000 pg/mL
50 - 25000 pg/mL
20 - 1000 pg/mL
Human Plasma K2 EDTA 200 -80
Cyclosporin A
Tacrolimus Sirolimus
1 - 500 ng/mL
0.1 - 50 ng/mL
0.1 - 50 ng/mL
Human Whole Blood K2 EDTA 50 -80
Desmosine 0.25 - 100 nM
(~0.13 - ~53 ng/mL)
Human Urine N/A 300 -20
Desmosine
Isodesmosine
30 - 2000 pM
(~16 - ~1050 pg/mL)
Human Serum N/A 500 -20
Diazepam
Desmethyldiazepam
0.5 - 500 ng/mL
0.1 - 100 ng/mL
Human Plasma K2 EDTA 50 -20
Digoxin 10 - 5000 pg/mL Human Plasma Lithium Heparin 100 -20
Duloxetine 1 - 500 ng/mL Human Plasma Lithium Heparin 100 -20
Enoxacin 5-5000ng/mL Human Plasma K2 EDTA 50 -20
Estradiol 5 - 1000 pg/mL Human Serum N/A 500 -20
Ethinylestradiol
Levonorgestrel
10 - 2000 pg/mL
0.1 - 20 ng/mL
Human Plasma Sodium Heparin 300 -20
Fluconazole 50 - 4000 ng/mL Human Plasma Lithium Heparin 50 -20
Fluconazole 50 - 50000 ng/mL Human Plasma K2 EDTA 20 -20
Fluticasone Propionate 1 - 500 pg/mL Human Plasma NaF/KOx 500 -20
Fluticasone Propionate
(High Range)
Salmeterol
5 - 1000 pg/mL
1 - 250 pg/mL
Human Plasma NaF/KOx 500 -20
Fluticasone Propionate
(Low Range)
Salmeterol
1 - 250 pg/mL Human Plasma NaF/KOx 500 -20
Fluvastatin 1 - 1000 ng/mL Human Plasma K2 EDTA 50 -20
Fluvoxamine 5-1200 ng/ml Human Plasma K2 EDTA 50 -20
Formoterol 0.250 - 125 pg/mL Human Plasma NaF/KOx 500 -20
Furosemide 10 - 5000 ng/mL Human Plasma Lithium Heparin 100 -20
Gemfibozil
Gemfibrozil 1-O-β-glucuronide
50 - 25000 ng/mL Human Plasma K2 EDTA 20 -20
Glucagon 15 - 250 pg/mL Human Plasma K3 EDTA 200 -80
Hydromorphone
Naloxone
Hydromorphone-3β-Glucuronide Naloxone-3β-Glucuronide
10 - 2500 pg/mL
100 - 2500 pg/mL
100 - 25000 pg/mL
Low range: 100 - 25000 pg/mL
High range: 1000 - 250000 pg/mL
Human Plasma K2 EDTA 200 -20
4β-Hydroxycholesterol 1 - 500 ng/mL Human Plasma K2 EDTA 50 -80
Ibuprofen 1 - 100 µg/mL Human Plasma Lithium Heparin 50 -20
Ibuprofen (R and S) 0.1 - 50 µg/mL Human Plasma Lithium Heparin 50 -80
Itraconazole
Hydroxyitraconazole
5 -2000 ng/mL Human Plasma K2 EDTA 50 -20
Levodopa
Carbidopa
3-OMD
50 - 7500 ng/mL
10 - 1500 ng/mL
200 - 30000 ng/mL
Human Plasma K2 EDTA 50 -80
Levofloxacin 20 - 20000 ng/mL Human Plasma Sodium Heparin 50 -80
LTE4 (Leukotriene E4) 8 - 500 pg/mL Human Urine N/A 1000 -80
Midazolam
1-OH Midazolam
4-OH Midazolam
0.1 - 100 ng/mL Human Plasma K2 EDTA 100 -20
Morphine
Morphine-3-Glucoronide Morphine-6-Glucoronide
0.1 - 100 ng/mL
5 - 3000 ng/mL
1 - 500 ng/mL
Human Plasma K2 EDTA 100 -20
Moxifloxacin 50 - 5000 ng/mL Human Plasma Lithium Heparin 50 -20
Naloxone
Naloxone-3β-Glucoronide
30 - 25000 pg/mL Human Plasma K2 EDTA 200 -20
Naproxen 0.25 - 100 µg/mL Human Plasma K2 EDTA 50 -20
Omeprazole 1 - 500 ng/mL Human Plasma Lithium Heparin 100 -80
Paclitaxel 10 – 10000 ng/mL Human Plasma K2 EDTA 25 -20
Paracetamol Low Range: 50 - 5000 ng/mL
High Range: 200 - 20000 ng/mL
Human Plasma K2 EDTA 50 -20
Paracetamol
Pseudoephedrine
50 - 5000 ng/mL
2 - 500 ng/mL
Human Plasma Lithium Heparin 100 -20
Paroxetine 0.05 - 50 ng/mL Human Plasma K2 EDTA 50 -20
Posaconazole 5 - 5000 ng/mL Human Plasma Lithium Heparin 50 -20
Pravastatin 0.5 - 250 ng/mL Human Plasma K2 EDTA 100 -20
8-Iso Prostaglandin F2alpha 25 - 20000 pg/mL Human Urine N/A 1000 -20
Repaglinide
3-Hydroxy Repaglinide
0.1 - 50 ng/mL Human Plasma K2 EDTA 100 -80
Rifampicin 20 - 20000 ng/mL Human Plasma K2 EDTA 50 -80
Rimonabant 1 - 600 ng/mL Human Plasma Lithium Heparin 50 -20
Ritonavir
Lopinavir
4 - 3200 ng/mL
20 - 16000 ng/mL
Human Plasma K2 EDTA 100 -20
Rosuvastatin 0.2 - 100 ng/mL Human Plasma K3 EDTA 200 -80
Scopolamine
Physostigmine
0.05 - 25 ng/mL
0.1 - 50 ng/mL
Human Plasma Lithium Heparin (with Neostigmine as stabiliser) 100 -80
Simvastatin
Simvastatin Acid
0.1 - 50 ng/mL Human Plasma Lithium Heparin 100 -80
Testosterone 0.05 - 30 ng/mL Human Serum N/A 100 -20
Testosterone Dihydrotestosterone 20 - 10000 pg/mL Human Serum N/A 500 -20
Testosterone Undecanoate Dihydrotestosterone Undecanoate 1 - 500 ng/mL
1.5 - 250 ng/mL
Human Serum N/A 200 -20
Ticlopidine 2 - 2000 ng/ml Human Plasma K2 EDTA 20 -20
Tiotropium 0.25 - 50 pg/mL Human Plasma K2 EDTA 200 -20
Tobramycin 5 - 500 ng/mL Human Plasma Lithium Heparin 50 -80
Tolvaptan 1 - 1000 ng/mL Human Plasma Sodium Heparin 50 -20
Warfarin (R and S) 10 - 2000 ng/mL Human Plasma K2 EDTA 1000 -20